Group B Streptococcal Toxic Shock Syndrome and covR/S Mutations Revisited

Emerg Infect Dis. 2017 Jan;23(1):150-152. doi: 10.3201/eid2301.161063.

Abstract

Gene mutations in the virulence regulator CovR/S of group A Streptococcus play a substantial role in the pathogenesis of streptococcal toxic shock syndrome. We screened 25 group B Streptococcus (GBS) isolates obtained from patients with streptococcal toxic shock syndrome and found only 1 GBS clone harboring this kind of mutation.

Keywords: STSS; bacteria; group B Streptococcus; streptococcal toxic shock syndrome; streptococci; toxic shock syndrome; two-component system.

Publication types

  • Letter
  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Female
  • Gene Expression Regulation, Bacterial*
  • Humans
  • Infant, Newborn
  • Male
  • Middle Aged
  • Multilocus Sequence Typing
  • Mutation*
  • Repressor Proteins / genetics*
  • Repressor Proteins / metabolism
  • Serotyping
  • Shock, Septic / microbiology*
  • Shock, Septic / mortality
  • Shock, Septic / pathology
  • Streptococcal Infections / microbiology*
  • Streptococcal Infections / mortality
  • Streptococcal Infections / pathology
  • Streptococcus agalactiae / classification
  • Streptococcus agalactiae / genetics
  • Streptococcus agalactiae / pathogenicity*
  • Survival Analysis
  • Virulence
  • Virulence Factors / genetics*
  • Virulence Factors / metabolism

Substances

  • Bacterial Proteins
  • CovR protein, Streptococcus agalactiae
  • Repressor Proteins
  • Virulence Factors