Surfactant- and oxidant-stable alkaline proteases from Bacillus invictae: Characterization and potential applications in chitin extraction and as a detergent additive

Int J Biol Macromol. 2017 Mar:96:272-281. doi: 10.1016/j.ijbiomac.2016.12.035. Epub 2016 Dec 14.

Abstract

A newly alkaline proteases producing strain was isolated from sea water. The strain was identified as Bacillus invictae on the basis of biochemical characteristics and 16S rRNA sequence analysis. The crude protease activity showed an optimal activity at approximately 60°C and in wide pH interval ranging from 9.0 to 11.0. At least six clear caseinolytic protease bands were observed in a zymogram. Phenylmethylsulfonyl fluoride (PMSF), a serine-protease inhibitor, was found to inhibit completely the protease activity. The crude alkaline proteases showed high stability toward solid and liquid detergents. Furthermore, wash performance analysis revealed that the crude enzyme could effectively remove blood stain when added to commercial detergent. In addition, the crude proteases were found to be effective in the deproteinization of shrimp shell waste. The percent of protein removal after 3h of hydrolysis at 50°C with an E/S ratio of 10U/mg of protein or after fermentation by the strain were about 76% and 82%, respectively. Thus, the results of the present study showed that the crude proteases of B. invectae could be effectively used in several industrial applications, as an eco-friendly agent.

Keywords: Bacillus invictae; Chitin; Detergent-alkaline proteases.

MeSH terms

  • Bacillus / enzymology*
  • Bacterial Proteins / antagonists & inhibitors
  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / metabolism*
  • Calcium / pharmacology
  • Chitin / isolation & purification*
  • Detergents / pharmacology*
  • Endopeptidases / chemistry*
  • Endopeptidases / metabolism*
  • Enzyme Inhibitors / pharmacology
  • Enzyme Stability / drug effects
  • Fermentation
  • Hydrogen-Ion Concentration
  • Metals / pharmacology
  • Oxidants / pharmacology*
  • Temperature
  • Waste Products

Substances

  • Bacterial Proteins
  • Detergents
  • Enzyme Inhibitors
  • Metals
  • Oxidants
  • Waste Products
  • Chitin
  • Endopeptidases
  • alkaline protease
  • Calcium