Cerebral Rhizomucor Infection Treated by Posaconazole Delayed-Release Tablets in an Allogeneic Stem Cell Transplant Recipient

Int J Infect Dis. 2017 Feb:55:24-26. doi: 10.1016/j.ijid.2016.12.014. Epub 2016 Dec 14.

Abstract

Mucormycosis (zygomycosis) is an emerging fungal disease in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. A 30-year-old woman diagnosed with acute myelomonocytic leukemia and needing allo-HSCT presented pulmonary and cerebral infection due to Rhizomucor pusillus. This fungal infection was treated with surgical treatment and posaconazole delayed-release tablets. This strategy allowed reaching high drug levels that could not be obtained with the posaconazole solution.

Keywords: Mucormycosis; Posaconazole delayed-release tablets; Rhizomucor pusillus; Zygomycosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antifungal Agents / therapeutic use*
  • Delayed-Action Preparations
  • Fatal Outcome
  • Female
  • Humans
  • Immunocompromised Host
  • Leukemia, Myelomonocytic, Acute / immunology
  • Leukemia, Myelomonocytic, Acute / surgery*
  • Mucormycosis / diagnosis
  • Mucormycosis / drug therapy*
  • Mucormycosis / immunology
  • Mucormycosis / microbiology*
  • Rhizomucor / drug effects
  • Stem Cell Transplantation*
  • Tablets
  • Transplantation, Homologous
  • Triazoles / therapeutic use*

Substances

  • Antifungal Agents
  • Delayed-Action Preparations
  • Tablets
  • Triazoles
  • posaconazole