Biopsy of the sentinel node in lung cancer

Med Clin (Barc). 2017 Mar 22;148(6):257-259. doi: 10.1016/j.medcli.2016.10.034. Epub 2016 Dec 16.
[Article in English, Spanish]

Abstract

Introduction and objective: Mediastinal lymph node involvement can be understaged in cases of lung cancer (up to 20% in stage i). Sentinel node detection is a standard technique recommended in breast cancer and melanoma action guidelines, and could also be useful in cases of lung cancer.

Material and methods: Considering the detection of the sentinel node in non-small cell lung cancer (NSCLC) as feasible, a prospective cohort study was carried out on 48 patients with resectable NSCLC, using the intraoperative injection of colloid sulphate technetium-99.

Results: The radioisotope migrated in all cases. The procedure's sensitivity was 88.24%, its accuracy was 95.83%, its negative predictive value was 93.94% and the false negative rate was 11.76%. No complications were associated with this technique.

Conclusions: The detection of a sentinel node in NSCLC with the intraoperative injection of the isotope is feasible and safe, and allows for detection and sensitivity rates comparable to those of other tumour types.

Keywords: Cáncer de pulmón; Ganglio centinela; Lung cancer; Micrometastasis; Micrometástasis; Sentinel node; Skip metastases; Skip metástasis.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Non-Small-Cell Lung / diagnostic imaging
  • Carcinoma, Non-Small-Cell Lung / pathology*
  • Carcinoma, Non-Small-Cell Lung / surgery
  • Female
  • Humans
  • Intraoperative Care / methods*
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / pathology*
  • Lung Neoplasms / surgery
  • Lymphatic Metastasis
  • Male
  • Mediastinum
  • Middle Aged
  • Prospective Studies
  • Radionuclide Imaging
  • Radiopharmaceuticals
  • Sensitivity and Specificity
  • Sentinel Lymph Node Biopsy / methods*
  • Technetium Tc 99m Sulfur Colloid

Substances

  • Radiopharmaceuticals
  • Technetium Tc 99m Sulfur Colloid