CLL-cell-mediated MDSC induction by exosomal miR-155 transfer is disrupted by vitamin D

Leukemia. 2017 Apr;31(4):985-988. doi: 10.1038/leu.2016.378. Epub 2016 Dec 23.

Authors

H Bruns¹, M Böttcher¹, M Qorraj¹, M Fabri², S Jitschin¹, J Dindorf³, L Busch¹, R Jitschin¹, A Mackensen¹, D Mougiakakos¹

Affiliations

¹ Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany.
² Department of Dermatology, University of Cologne, Cologne, Germany.
³ Department of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany.

PMID: 28008175
DOI: 10.1038/leu.2016.378

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Exosomes / drug effects*
Female
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
Leukocytes, Mononuclear / drug effects
Lipopolysaccharide Receptors / genetics
Male
MicroRNAs / genetics*
Middle Aged
Monocytes / drug effects
Myeloid-Derived Suppressor Cells / drug effects*
Vitamin D / therapeutic use*

Substances

Lipopolysaccharide Receptors
MIRN155 microRNA, human
MicroRNAs
Vitamin D