Bimetallic Pt-based nanodendrites are of particular interest in various catalytic applications due to their high surface areas and low densities. Herein, we provide a facile method for one-pot synthesis of PtRu nanodendrites via the co-reduction of Pt and Ru precursors in oleylamine by H2. The as-fabricated PtRu nanodendrites exhibit superior catalytic activity and durability compared with PtRu nanocrystals (NCs), synthesized under the same reaction conditions, and the commercial Pt/C catalyst towards the methanol oxidation reaction (MOR).