Objective: To investigate the PET-CT manifestation and clinical features of patients with Waldenstrom macroglobulinemia(WM) .
Methods: The clinical features, laboratorial examination results and PET-CT manifestation of 12 patients with WM were analyzed retrospectively.
Results: The average age of 12 patients with WM was 63.5 years old, the most common incipient symptoms were fatigue and hyperviscosity syndrome. The median SUVmax of bone marrow was 4.9 (range of 2.1 to 21.9), with diffusely increased 18F-FDG uptake in all the patients. In 6 patients, the median SUVmax of splenomegaly and lymphadenectasis was 3.2 (range of 2.3 to 5.2) and 5.2 (range of 3.6 to 11.2), respectively. The SUVmax of bone marrow, splenomegaly and lymphadenectasis did not related with white blood cell count, hemoglobin level, blood platelet count, β2- microglobulin level and serum monoclonal IgM of such patients, respectively (both P>0.5). In univariate analysis, serum monoclonal IgM and the SUVmax of lymphadenectasis were found to be the prognostic factors (both P<0.5).
Conclusion: The 18F-FDG PET-CT feature of Waldenstrom macroglobulinemia has some characteristics which are helpful for setting up the clinical therapeutic schedule.