Abstract
Four resected specimens of hepatic angiomyolipoma in which uptake of Sonazoid was observed in the postvascular phase of Sonazoid-enhanced ultrasonography were analyzed. Macrophage localization in the tumor was revealed pathologically by immunohistochemical staining for CD68. CD68-positive cells were observed in the tumor in all cases. The density of CD68-positive cells was 100/mm2, and the ratio of CD68-positive cell density in the tumor to that in the surrounding parenchyma was 32-171%. These results suggested that the uptake of the contrast agent Sonazoid was related to the density of CD68-positive cells.
© 2016 S. Karger AG, Basel.
MeSH terms
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Adult
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Angiography
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Angiomyolipoma / blood supply
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Angiomyolipoma / diagnostic imaging
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Angiomyolipoma / metabolism
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Angiomyolipoma / pathology*
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Antigens, CD / biosynthesis*
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Antigens, Differentiation, Myelomonocytic / biosynthesis*
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Contrast Media / pharmacokinetics
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Female
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Ferric Compounds / pharmacokinetics
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Humans
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Immunohistochemistry
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Iron / pharmacokinetics
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Liver Neoplasms / blood supply
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Liver Neoplasms / diagnostic imaging
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Liver Neoplasms / metabolism
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Liver Neoplasms / pathology*
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Macrophages / metabolism
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Macrophages / pathology
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Male
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Middle Aged
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Oxides / pharmacokinetics
Substances
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Antigens, CD
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Antigens, Differentiation, Myelomonocytic
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CD68 antigen, human
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Contrast Media
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Ferric Compounds
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Oxides
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Sonazoid
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Iron