Draft genome sequence of a multidrug-resistant beta-lactamase OXA-357-producing Acinetobacter pittii ST865 clinical isolate from China

Braz J Microbiol. 2017 Apr-Jun;48(2):196-197. doi: 10.1016/j.bjm.2016.10.020. Epub 2016 Dec 14.

Abstract

Worldwide increasing emergence of carbapenem-resistant Acinetobacter spp. has rendered the limited availability of effective antimicrobial agents and has become a major public health concern. In this study, we report the draft genome sequence of A. pittii TCM156, a multidrug-resistant isolate that harbored the blaOXA-357 gene. The genome sequence was further analyzed by various bioinformatics methods. The genome size was estimated to be 3,807,313bp with 3508 predicted coding regions and G+C content is 38.7%. These findings have raised awareness of the possible emergence of OXA-type enzyme-producing A. pittii isolate in China.

Keywords: Acinetobacter pittii; Multidrug-resistance; Whole genome sequencing (WGS); bla(OXA-357).

MeSH terms

  • Acinetobacter / drug effects
  • Acinetobacter / enzymology
  • Acinetobacter / genetics*
  • Acinetobacter / isolation & purification
  • Acinetobacter Infections / microbiology*
  • Base Composition
  • China
  • DNA, Bacterial / chemistry*
  • DNA, Bacterial / genetics
  • Drug Resistance, Multiple, Bacterial*
  • Genome, Bacterial*
  • Sequence Analysis, DNA*
  • beta-Lactamases / metabolism*

Substances

  • DNA, Bacterial
  • beta-Lactamases