Implementation of a Rapid Genotypic Assay to Promote Targeted Ciprofloxacin Therapy of Neisseria gonorrhoeae in a Large Health System

Lao-Tzu Allan-Blitz; Romney M Humphries; Peera Hemarajata; Ashima Bhatti; Mark W Pandori; Mark J Siedner; Jeffrey D Klausner

doi:10.1093/cid/ciw864

Implementation of a Rapid Genotypic Assay to Promote Targeted Ciprofloxacin Therapy of Neisseria gonorrhoeae in a Large Health System

Clin Infect Dis. 2017 May 1;64(9):1268-1270. doi: 10.1093/cid/ciw864.

Authors

Lao-Tzu Allan-Blitz¹, Romney M Humphries², Peera Hemarajata², Ashima Bhatti³, Mark W Pandori⁴, Mark J Siedner⁵, Jeffrey D Klausner^{6

7}

Affiliations

¹ David Geffen School of Medicine, University of California Los Angeles, CA, USA.
² Department of Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
³ Fielding School of Public Health, University of California, Los Angeles (UCLA), USA.
⁴ Alameda County Department of Public Health, Oakland, California, USA.
⁵ Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, USA.
⁶ Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
⁷ Department of Epidemiology, Fielding School of Public Health, UCLA, California, USA.

Abstract

Multidrug-resistant Neisseria gonorrhoeae is a top threat to public health. In November 2015, UCLA Health introduced a rapid gyrase A (gyrA) genotypic assay for prediction of Neisseria gonorrhoeae susceptibility to ciprofloxacin. We found a significant reduction in ceftriaxone use with a concomitant increase in targeted therapy.

Keywords: Neisseria gonorrhoeae; antibiotic resistance.; ciprofloxacin; gyrA.

MeSH terms

Anti-Bacterial Agents / therapeutic use*
Ceftriaxone / therapeutic use
Ciprofloxacin / therapeutic use*
DNA Gyrase / genetics
Drug Utilization
Female
Genotyping Techniques / methods*
Gonorrhea / drug therapy*
Gonorrhea / microbiology*
Humans
Male
Microbial Sensitivity Tests / methods*
Neisseria gonorrhoeae / classification
Neisseria gonorrhoeae / genetics*
Neisseria gonorrhoeae / isolation & purification

Substances

Anti-Bacterial Agents
Ciprofloxacin
Ceftriaxone
DNA Gyrase

Abstract

MeSH terms

Substances

Grants and funding