The central nervous system microenvironment influences the leukemia transcriptome and enhances leukemia chemo-resistance

Haematologica. 2017 Apr;102(4):e136-e139. doi: 10.3324/haematol.2016.152926. Epub 2016 Dec 29.

Authors

Jeffrey S Gaynes¹, Leslie M Jonart¹, Edward A Zamora¹, Jordan A Naumann¹, Nathan P Gossai¹, Peter M Gordon²

Affiliations

¹ Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA.
² Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA [email protected].

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / pharmacology
Bone Marrow Cells / drug effects*
Bone Marrow Cells / metabolism
Bone Marrow Cells / pathology
Central Nervous System / drug effects
Central Nervous System / metabolism*
Central Nervous System / pathology
Coculture Techniques
Cytarabine / pharmacology
Drug Resistance, Neoplasm / genetics*
Gene Expression Regulation, Leukemic*
Humans
Mice
Mice, Inbred NOD
Neoplasm Proteins / genetics*
Neoplasm Proteins / metabolism
Neoplasm Transplantation
Neurons / metabolism
Neurons / pathology
Pre-B-Cell Leukemia Transcription Factor 1 / genetics
Pre-B-Cell Leukemia Transcription Factor 1 / metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
Recurrence
Signal Transduction
Transcriptome*
Transplantation, Heterologous
Tumor Microenvironment / genetics

Substances

Antineoplastic Agents
Neoplasm Proteins
Pre-B-Cell Leukemia Transcription Factor 1
PBX1 protein, human
Cytarabine

Grants and funding