Anti-MDA5 dermatomyositis mimicking psoriatic arthritis

Reumatol Clin (Engl Ed). 2018 Jul-Aug;14(4):224-226. doi: 10.1016/j.reuma.2016.10.010. Epub 2016 Dec 28.
[Article in English, Spanish]

Abstract

Dermatomyositis causes inflammation and damage of muscle and skin, and sometimes involves internal organs, especially lung parenchyma. Patients with dermatomyositis still represent a diagnostic challenge because of the rarity of this disease and the lack of specificity of some of its cutaneous manifestations. Herein, we describe the case of a patient with dermatomyositis, initially diagnosed as psoriatic arthritis, in which the performance of anti-melanoma differentiation-associated gene 5 (MDA5) antibodies was decisive to establish a definitive diagnosis.

Keywords: Artritis psoriásica; Dermatomiositis; Dermatomyositis; Melanoma differentiation-associated protein gene 5; Proteína asociada a la diferenciación del melanoma 5; Psoriatic arthritis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Arthritis, Psoriatic / diagnosis*
  • Autoantibodies / blood*
  • Biomarkers / blood
  • Dermatomyositis / blood
  • Dermatomyositis / diagnosis*
  • Dermatomyositis / immunology
  • Diagnosis, Differential
  • Diagnostic Errors
  • Female
  • Humans
  • Interferon-Induced Helicase, IFIH1 / immunology*

Substances

  • Autoantibodies
  • Biomarkers
  • IFIH1 protein, human
  • Interferon-Induced Helicase, IFIH1