[3+2] Cycloaddition of azide with aldehyde hydrazone through an aminyl radical-polar crossover strategy

Zhongkai Wu; Pan Xu; Nengneng Zhou; Yingqian Duan; Muliang Zhang; Chengjian Zhu

doi:10.1039/c6cc08779e

[3+2] Cycloaddition of azide with aldehyde hydrazone through an aminyl radical-polar crossover strategy

Chem Commun (Camb). 2017 Jan 17;53(6):1045-1047. doi: 10.1039/c6cc08779e.

Authors

Zhongkai Wu¹, Pan Xu¹, Nengneng Zhou¹, Yingqian Duan¹, Muliang Zhang¹, Chengjian Zhu²

Affiliations

¹ State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China. [email protected].
² State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China. [email protected] and State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai, 200032, P. R. China.

PMID: 28044151
DOI: 10.1039/c6cc08779e

Abstract

A novel approach to obtain functionalized tetrazoles by a [3+2] cycloaddition of azide with aldehyde hydrazone is reported. This reaction features a broad substrate scope and mild reaction conditions through an aminyl radical-polar crossover strategy.