Les inhibiteurs des points de contrôle immunitaire dans le cancer bronchique non à petites cellules de stade avancé

Bull Cancer. 2016 Nov:103 Suppl 1:S138-S143. doi: 10.1016/S0007-4551(16)30371-X.
[Article in French]

Abstract

IMMUNE CHECKPOINT INHIBITORS IN ADVANCED NON-SMALL CELL LUNG CANCER: T-cell-directed strategies represent currently a major advance in the treatment of advanced non-small-cell lung cancer, regarding their efficacy and tolerance. Nivolumab and pembrolizumab, two monoclonal antibodies targeting programmed cell death protein 1 (PD-1) have shown their efficacy in phase III studies. Several other drugs are developed and the benefit of association is being evaluated. In this article, we propose to summarize the clinical development of immune checkpoint inhibitors in patients with advanced non-small cell lung cancer.

Keywords: Cancer bronchique non à; Immunotherapy; Immunothérapie; Non-small-cell lung cancer; PD-1; PD-L1; petites cellules.

MeSH terms

  • Antibodies, Monoclonal / therapeutic use*
  • Antibodies, Monoclonal, Humanized / therapeutic use*
  • Antineoplastic Agents / therapeutic use*
  • Carcinoma, Non-Small-Cell Lung / mortality
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Carcinoma, Non-Small-Cell Lung / therapy*
  • Cell Cycle Checkpoints / drug effects*
  • Cell Cycle Checkpoints / immunology
  • Clinical Trials as Topic
  • Docetaxel
  • Humans
  • Immunotherapy / methods*
  • Lung Neoplasms / mortality
  • Lung Neoplasms / pathology
  • Lung Neoplasms / therapy*
  • Nivolumab
  • Programmed Cell Death 1 Receptor / antagonists & inhibitors
  • Taxoids / therapeutic use

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents
  • Programmed Cell Death 1 Receptor
  • Taxoids
  • Docetaxel
  • Nivolumab
  • pembrolizumab