Rare myopathy associated to MGUS, causing heart failure and responding to chemotherapy

Nicolas Belhomme; Adel Maamar; Thomas Le Gallou; Marie-Christine Minot-Myhié; Antoine Larralde; Nicolas Champtiaux; Olivier Benveniste; Sarah Leonard-Louis; Olivier Decaux; Alain Lescoat; Yves Le Tulzo

doi:10.1007/s00277-016-2916-3

Rare myopathy associated to MGUS, causing heart failure and responding to chemotherapy

Ann Hematol. 2017 Apr;96(4):695-696. doi: 10.1007/s00277-016-2916-3. Epub 2017 Jan 5.

Authors

Affiliations

¹ Service de Médecine Interne, CHU Pontchaillou, 2, rue Henri Le Guilloux, 35000, Rennes, France. [email protected].
² Service des Maladies Infectieuses et de Réanimation Médicale, CHU Pontchaillou, 2, rue Henri Le Guilloux, 35000, Rennes, France.
³ Service de Médecine Interne, CHU Pontchaillou, 2, rue Henri Le Guilloux, 35000, Rennes, France.
⁴ Service de Neurologie, CHU Pontchaillou, 2, rue Henri Le Guilloux, 35000, Rennes, France.
⁵ Service de Radiologie et d'Imagerie Médicale, CHU Pontchaillou, 2, rue Henri Le Guilloux, 35000, Rennes, France.
⁶ Département de Médecine Interne et Immunologie Clinique, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
⁷ DHU I2B, AP-HP, INSERM U974, UPMC Sorbonne Universités, Paris, France.
⁸ Service de Neurologie, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.
⁹ Service des Maladies Infectieuses et Réanimation Médicale, CHU Pontchaillou, 2, rue Henri Le Guilloux, 35000, Rennes, France.
¹⁰ Inserm-CIC1414, 35043, Rennes, France.

PMID: 28058489
DOI: 10.1007/s00277-016-2916-3

No abstract available

Keywords: Chemotherapy; Electron microscopy; Heart failure; Monoclonal gammopathy of unknown significance; Nemaline myopathy related cardiomyopathy; Sarcoplasmic rods; Sporadic late onset nemaline myopathy.

Publication types

Case Reports
Letter

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Bortezomib / administration & dosage
Cyclophosphamide / administration & dosage
Dexamethasone / administration & dosage
Heart Failure / drug therapy*
Heart Failure / etiology*
Humans
Male
Middle Aged
Monoclonal Gammopathy of Undetermined Significance / complications*
Monoclonal Gammopathy of Undetermined Significance / drug therapy*
Monoclonal Gammopathy of Undetermined Significance / pathology
Myopathies, Nemaline / drug therapy*
Myopathies, Nemaline / etiology*
Treatment Outcome

Substances

Bortezomib
Dexamethasone
Cyclophosphamide