Copper Complexes as Bioinspired Models for Lytic Polysaccharide Monooxygenases

Inorg Chem. 2017 Feb 6;56(3):1023-1026. doi: 10.1021/acs.inorgchem.6b02165. Epub 2017 Jan 6.

Abstract

We report here two copper complexes as first functional models for lytic polysaccharide monooxygenases, mononuclear copper-containing enzymes involved in recalcitrant polysaccharide breakdown. These complexes feature structural and spectroscopic properties similar to those of the enzyme. In addition, they catalyze oxidative cleavage of the model substrate p-nitrophenyl-β-d-glucopyranoside. More importantly, a particularly stable copper(II) hydroperoxide intermediate is detected in the reaction conditions.

MeSH terms

  • Biocatalysis
  • Copper / chemistry*
  • Copper / metabolism
  • Mixed Function Oxygenases / chemistry*
  • Mixed Function Oxygenases / metabolism
  • Models, Molecular
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / metabolism
  • Polysaccharides / chemistry*
  • Polysaccharides / metabolism
  • Quantum Theory
  • Thermoascus / enzymology

Substances

  • Organometallic Compounds
  • Polysaccharides
  • Copper
  • Mixed Function Oxygenases