Abstract
Recognition of non-SCID and secondary causes of T cell lymphopenia detected by TREC newborn screening is important in directing subsequent care and identifying those who would not benefit from more invasive interventions. Here, we report two infants with low TRECs and severe, but self-resolving, T cell lymphopenia identified by SCID NBS that were caused by in utero exposure to purine antimetabolites.
MeSH terms
-
Aza Compounds / adverse effects*
-
Aza Compounds / therapeutic use
-
Female
-
Humans
-
Immunosuppressive Agents / adverse effects*
-
Immunosuppressive Agents / therapeutic use
-
Infant
-
Infant, Newborn
-
Lymphocyte Count
-
Lymphopenia / diagnosis*
-
Lymphopenia / genetics
-
Lymphopoiesis / drug effects
-
Male
-
Mercaptopurine / adverse effects*
-
Mercaptopurine / therapeutic use
-
Neonatal Screening
-
Pathology, Molecular
-
Pregnancy
-
Prenatal Exposure Delayed Effects / diagnosis*
-
Purines / antagonists & inhibitors*
-
Receptors, Antigen, T-Cell / genetics*
-
Severe Combined Immunodeficiency / diagnosis*
-
T-Lymphocytes / physiology*
-
United States
Substances
-
Aza Compounds
-
Immunosuppressive Agents
-
Purines
-
Receptors, Antigen, T-Cell
-
Mercaptopurine
-
purine