An NgAgo tool for genome editing: did CRISPR/Cas9 just find a competitor?

Genes Dis. 2016 Sep;3(3):169-170. doi: 10.1016/j.gendis.2016.06.001. Epub 2016 Jul 9.

Abstract

While CRISPR/Cas9-mediated genome editing technology has been experiencing a rapid transformation during the past few years, a recent report on NgAgo-mediated single-stranded DNA-guided genome editing may offer an attractive alternative for genome manipulation. While it's too early to predict whether NgAgo will be able to compete with or be superior to CRISPR/Cas9, the scientific community is anxiously waiting for further optimization and broader applications of the NgAgo genome editing technology.

Keywords: Argonautes; CRISPR; Cas9; Genome editing; NgAgo; Nucleases; gRNA guide; ssDNA guide.