Phosphoproteomic analysis reveals hyperactivation of mTOR/STAT3 and LCK/Calcineurin axes in pediatric early T-cell precursor ALL

Leukemia. 2017 Apr;31(4):1007-1011. doi: 10.1038/leu.2017.13. Epub 2017 Jan 13.

Authors

V Serafin¹, V Lissandron¹, B Buldini¹, S Bresolin¹, M Paganin¹, F Grillo¹, N Andriano², C Palmi², G Cazzaniga², S Marmiroli³, V Conter⁴, G Basso¹, B Accordi¹

Affiliations

¹ Department of Woman's and Child's Health, University of Padova, Padova, Italy.
² Centro Ricerca Tettamanti, Department of Pediatrics, University of Milano-Bicocca, Fondazione MBBM, Monza, Italy.
³ Department of Surgery, Medicine, Dentistry and Morphology, University of Modena and Reggio Emilia, Modena, Italy.
⁴ Center of Hemato-Oncology, Department of Pediatrics, University of Milano-Bicocca, Fondazione MBBM, Ospedale San Gerardo, Monza, Italy.

PMID: 28082737
DOI: 10.1038/leu.2017.13

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Calcineurin / metabolism*
Cells, Cultured
Hematopoietic Stem Cells / metabolism
Humans
Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / metabolism*
Myeloid Cells / metabolism
Phosphorylation / physiology*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
Precursor Cells, T-Lymphoid / metabolism*
Proteome / metabolism
STAT3 Transcription Factor / metabolism*
TOR Serine-Threonine Kinases / metabolism*
Transcriptome / physiology

Substances

Proteome
STAT3 Transcription Factor
STAT3 protein, human
MTOR protein, human
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
TOR Serine-Threonine Kinases
Calcineurin