Mathematical analysis of a quorum sensing induced biofilm dispersal model and numerical simulation of hollowing effects

Math Biosci Eng. 2017 Jun 1;14(3):625-653. doi: 10.3934/mbe.2017036.

Abstract

We analyze a mathematical model of quorum sensing induced biofilm dispersal. It is formulated as a system of non-linear, density-dependent, diffusion-reaction equations. The governing equation for the sessile biomass comprises two non-linear diffusion effects, a degeneracy as in the porous medium equation and fast diffusion. This equation is coupled with three semi-linear diffusion-reaction equations for the concentrations of growth limiting nutrients, autoinducers, and dispersed cells. We prove the existence and uniqueness of bounded non-negative solutions of this system and study the behavior of the model in numerical simulations, where we focus on hollowing effects in established biofilms.

MeSH terms

  • Biofilms*
  • Biomass
  • Computer Simulation
  • Models, Biological*
  • Quorum Sensing*