Antibiotic Coating of the Artificial Urinary Sphincter (AMS 800): Is it Worthwhile?

Urology. 2017 May:103:179-184. doi: 10.1016/j.urology.2016.12.056. Epub 2017 Jan 16.

Abstract

Objective: To investigate the impact of the antibiotic coating InhibiZone on the infection and explantation rates of the AMS 800 in comparison to the AMS 800 without InhibiZone.

Materials and methods: We retrospectively identified 305 patients with an AMS 800 in a multicenter cohort study. Patients were subsequently divided into InhibiZone and without InhibiZone-coated groups. Infection and explantation rates were analyzed by univariate and consecutively by multivariate logistic regression adjusted to variable risk factors. The infection-free interval was estimated by Kaplan-Meier plot and compared by the log-rank test. A P value below .05 was considered statistically significant.

Results: We identified 47 patients with InhibiZone and 258 without InhibiZone coating. In univariate analysis, we could not identify a significant difference in infection (P = .932) or explantation (P = .715) rates between the groups. In multivariate analysis, impaired wound healing (P = .008) and urethral erosion (P < .001) were independent predictors for infection. The InhibiZone coating neither demonstrated significant influence on the infection rate (P = .534) nor on the explantation rate (P = .214). There was no significant difference in estimated infection-free survival between the groups (P = .265).

Conclusion: The antibiotic coating of the AMS 800 had no significant impact on infection or explantation rates in our cohort.

Publication types

  • Multicenter Study

MeSH terms

  • Aged
  • Anti-Bacterial Agents / pharmacology*
  • Coated Materials, Biocompatible / pharmacology
  • Cohort Studies
  • Female
  • Humans
  • Long Term Adverse Effects* / diagnosis
  • Long Term Adverse Effects* / prevention & control
  • Male
  • Middle Aged
  • Outcome Assessment, Health Care
  • Prosthesis Design
  • Prosthesis-Related Infections* / diagnosis
  • Prosthesis-Related Infections* / prevention & control
  • Risk Assessment
  • Risk Factors
  • Urinary Incontinence / therapy
  • Urinary Sphincter, Artificial / adverse effects*
  • Urinary Tract Infections* / diagnosis
  • Urinary Tract Infections* / etiology
  • Urinary Tract Infections* / prevention & control

Substances

  • Anti-Bacterial Agents
  • Coated Materials, Biocompatible