Germline IKAROS mutation associated with primary immunodeficiency that progressed to T-cell acute lymphoblastic leukemia

Leukemia. 2017 May;31(5):1221-1223. doi: 10.1038/leu.2017.25. Epub 2017 Jan 18.
No abstract available

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Progression
  • Female
  • Germ-Line Mutation*
  • Humans
  • Ikaros Transcription Factor / genetics*
  • Immunologic Deficiency Syndromes / genetics*
  • Immunologic Deficiency Syndromes / pathology
  • Infant
  • Mice
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Receptor, Notch1 / genetics

Substances

  • IKZF1 protein, human
  • NOTCH1 protein, human
  • Receptor, Notch1
  • Ikaros Transcription Factor