Squamous cell carcinoma with enteric adenocarcinomatous differentiation

Patrick O Emanuel; Garrett Desman; Ben Tallon

doi:10.1111/cup.12910

Squamous cell carcinoma with enteric adenocarcinomatous differentiation

J Cutan Pathol. 2017 May;44(5):490-493. doi: 10.1111/cup.12910. Epub 2017 Feb 10.

Authors

Patrick O Emanuel^{1

2}, Garrett Desman², Ben Tallon^{3

4}

Affiliations

¹ Department of Pathology and Molecular Medicine, University of Auckland, Auckland, New Zealand.
² Division of Dermatopathology, Mount Sinai Medical Center, New York, New York.
³ Skin Dermatology Institute, Tauranga, New Zealand.
⁴ Pathlab Bay of Plenty, Tauranga, New Zealand.

PMID: 28111779
DOI: 10.1111/cup.12910

Abstract

We report a highly unusual case of a primary cutaneous squamous cell carcinoma (SCC) with intermixed enteric-type adenocarcinomatous dedifferentiation and a small component of undifferentiated mesenchymal differentiation. We believe this is the first time this form of phenotypic plasticity has been described in cutaneous SCC.

Keywords: CDX-2; adenocarcinoma; collision; squamous cell carcinoma; trans-differentiation.

Publication types

Case Reports

MeSH terms

Adenocarcinoma* / metabolism
Adenocarcinoma* / pathology
Aged, 80 and over
Carcinoma, Squamous Cell* / metabolism
Carcinoma, Squamous Cell* / pathology
Cell Dedifferentiation*
Female
Humans
Neoplasms, Second Primary* / metabolism
Neoplasms, Second Primary* / pathology
Skin Neoplasms* / metabolism
Skin Neoplasms* / pathology