Novel EGFR Exon 18 (G721R) Mutation in a Patient with Non-Small Cell Lung Carcinoma with Lack of Response to Afatinib

J Thorac Oncol. 2017 Feb;12(2):e16-e18. doi: 10.1016/j.jtho.2016.11.273.

Authors

Vamsidhar Velcheti¹, Monica Khunger², Mohamed E Abazeed³

Affiliations

¹ Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH. Electronic address: [email protected].
² Department of Internal Medicine, Cleveland Clinic, Cleveland, OH.
³ Department of Translational Hematology Oncology Research Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH.

PMID: 28115112
DOI: 10.1016/j.jtho.2016.11.273

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Afatinib
Carcinoma, Non-Small-Cell Lung / genetics*
Carcinoma, Non-Small-Cell Lung / pathology
Drug Resistance, Neoplasm
ErbB Receptors / genetics*
ErbB Receptors / metabolism
Exons*
Humans
Lung Neoplasms / enzymology
Lung Neoplasms / genetics*
Lung Neoplasms / pathology
Male
Middle Aged
Mutation*
Quinazolines / pharmacology

Substances

Quinazolines
Afatinib
EGFR protein, human
ErbB Receptors