[Neonatal alloimmunothrombocytopenia--effect of combination therapy consisting of i.v. immunoglobulin administration and transfusion of PLA1-negative maternal thrombocytes]

Monatsschr Kinderheilkd. 1989 Aug;137(8):458-62.
[Article in German]

Abstract

Two newborn infants with severe alloimmunothrombocytopenia due to maternal immunization against fetal PlA1-positive platelets were treated by a combination of i.v.-immunoglobulin (400 mg/kg b.w.) and a transfusion of maternal PlA1-negative platelets. In one infant this regimen was successful; the other one had to be retreated by i.v. immunoglobulin application (400 mg/kg b.w.) over a period of five days.

Publication types

  • Case Reports

MeSH terms

  • Antigens, Human Platelet*
  • Blood Platelets / immunology
  • Blood Transfusion*
  • Combined Modality Therapy
  • Erythroblastosis, Fetal / therapy*
  • Female
  • Humans
  • Immunization, Passive*
  • Infant, Newborn
  • Integrin beta3
  • Isoantigens / immunology*
  • Male
  • Platelet Transfusion*
  • Thrombocytopenia / immunology
  • Thrombocytopenia / therapy*

Substances

  • Antigens, Human Platelet
  • ITGB3 protein, human
  • Integrin beta3
  • Isoantigens