Chitosan-Gated Magnetic-Responsive Nanocarrier for Dual-Modal Optical Imaging, Switchable Drug Release, and Synergistic Therapy

Hui Wang; Qingxin Mu; Richard Revia; Kui Wang; Xuezhe Zhou; Peter J Pauzauskie; Shuiqin Zhou; Miqin Zhang

doi:10.1002/adhm.201601080

Chitosan-Gated Magnetic-Responsive Nanocarrier for Dual-Modal Optical Imaging, Switchable Drug Release, and Synergistic Therapy

Adv Healthc Mater. 2017 Mar;6(6):10.1002/adhm.201601080. doi: 10.1002/adhm.201601080. Epub 2017 Jan 25.

Authors

Hui Wang¹, Qingxin Mu¹, Richard Revia¹, Kui Wang¹, Xuezhe Zhou¹, Peter J Pauzauskie^{1

2}, Shuiqin Zhou³, Miqin Zhang¹

Affiliations

¹ Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA.
² Fundamental and Computational Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA, 99354, USA.
³ Department of Chemistry, The College of Staten Island, City University of New York, Staten Island, NY, 10314, USA.

Abstract

A dual-layer shell hollow nanostructure as drug carrier that provides instant on/off function for drug release and contrast enhancement for multimodal imaging is reported. The on-demand drug release is triggered by irradiation of an external magnetic field. The nanocarrier also demonstrates a high drug loading capacity and synergistic magnetic-thermal and chemotherapy.

Keywords: chitosan valve; drug carriers; multimodal imaging; on/off release; synergistic therapy.

MeSH terms

Animals
Cell Line, Tumor
Chitosan* / chemistry
Chitosan* / pharmacokinetics
Chitosan* / pharmacology
Drug Carriers* / chemistry
Drug Carriers* / pharmacokinetics
Drug Carriers* / pharmacology
Humans
Magnetic Fields*
Magnetic Resonance Imaging*
Mice
Nanoparticles* / chemistry
Nanoparticles* / therapeutic use
Tomography, Optical Coherence*

Substances

Drug Carriers
Chitosan

Grants and funding

R01 CA161953/CA/NCI NIH HHS/United States