Serological diagnosis of mumps: Value of the titration of specific IgG

Enferm Infecc Microbiol Clin (Engl Ed). 2018 Mar;36(3):172-174. doi: 10.1016/j.eimc.2016.10.012. Epub 2017 Jan 23.
[Article in English, Spanish]

Abstract

Introduction: The aim of this study was to evaluate a cut-off point of the titration of IgG by ELISA in the diagnosis of mumps.

Methods: A study was made of serum samples from 85 mumps cases (confirmed by PCR in saliva) and 2,351 controls of the general population of the Region of Madrid.

Results: The IgM detection was positive in 21 cases (sensitivity of 24.7%). The best cut-off point corresponded to IgG titres ≥4,900 (sensitivity of 64.7% and specificity of 86.1%). Among 42 patients immunised with at least one dose of measles mumps, rubella vaccine IgM was detected in 4 cases. However, the detection of IgG ≥4,900 was positive in 29 (sensitivity of 69.0%).

Conclusions: An IgG result of ≥4.900 was almost 5 times more probable in a patient with mumps than in a non-infected patient. The detection of high titres of IgG against mumps could improve the IgM results in vaccinated people.

Keywords: Diagnosis; Diagnóstico; IgG; Mumps; Parotiditis; Serology; Serología.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immunoglobulin G / blood*
  • Male
  • Middle Aged
  • Mumps / blood*
  • Mumps / diagnosis*
  • Serologic Tests
  • Young Adult

Substances

  • Immunoglobulin G