New strategies for cancer immunotherapy: targeting regulatory T cells

Francesca Finotello; Zlatko Trajanoski

doi:10.1186/s13073-017-0402-8

New strategies for cancer immunotherapy: targeting regulatory T cells

Genome Med. 2017 Jan 27;9(1):10. doi: 10.1186/s13073-017-0402-8.

Authors

Francesca Finotello¹, Zlatko Trajanoski²

Affiliations

¹ Biocenter, Division of Bioinformatics, Medical University of Innsbruck, Innsbruck, 6020, Austria.
² Biocenter, Division of Bioinformatics, Medical University of Innsbruck, Innsbruck, 6020, Austria. [email protected].

Abstract

The immunosuppressive action of regulatory T (T_reg) cells is one mechanism attributed to the limited success of cancer immunotherapies with checkpoint blockers. Two recent studies report distinct transcriptional profiles of tumor-infiltrating T_reg cells and expression of specific molecules, suggesting novel strategies to overcome resistance to cancer immunotherapy.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Immunotherapy / methods*
Neoplasms / immunology
Neoplasms / therapy*
T-Lymphocytes, Regulatory*