[Radical Chemoradiotherapy for Recurrent Esophageal Cancer after Curative Esophagectomy]

Gan To Kagaku Ryoho. 2016 Nov;43(12):1564-1566.
[Article in Japanese]

Abstract

Recurrent esophageal cancer has a poor prognosis.However, we sometimes encounter cases with long-term survival after radical treatment for recurrent esophageal cancer.We perform radical chemoradiotherapy aggressively when recurrent esophageal cancer is present in a limited area and is sufficiently localized to be treated by radiation therapy.From June 2010 to December 2014, 150 patients underwent curative esophagectomy for esophageal cancer.Forty -one cases relapsed and we treated 13 of them with radical chemoradiotherapy.Complete response(CR), non-CR/non-PD, and progressive disease(PD) were observed in 5, 6, and 2 cases, respectively.The CR rate was 38.4%.The median survival time from recurrence was 500± 39.7 days, and the 1-year and 3-year survival rates were 84.6% and 28.7%, respectively. Four out of 5 CR cases were single site recurrences.The other case was multiple and regrowth of the cancer was identified 253 days after the CR.These results suggest that radical chemoradiotherapy for recurrent esophageal cancer after curative esophagectomy can achieve long time survival, especially in cases with single site lymph node recurrence.

MeSH terms

  • Aged
  • Chemoradiotherapy*
  • Esophageal Neoplasms / therapy*
  • Esophagectomy
  • Female
  • Humans
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Recurrence
  • Treatment Outcome