In vitro evaluation of Selective Inhibitors of Nuclear Export (SINE) drugs KPT-185 and KPT-335 against canine mammary carcinoma and transitional cell carcinoma tumor initiating cells

Vet Comp Oncol. 2017 Dec;15(4):1455-1467. doi: 10.1111/vco.12289. Epub 2017 Jan 30.

Authors

J E Grayton¹, T Miller², H Wilson-Robles²

Affiliations

¹ Small Animal Clinical Sciences, Texas A&M University College of Veterinary Medicine and Biomedical Sciences, College Station, TX, USA.
² Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.

PMID: 28133930
DOI: 10.1111/vco.12289

No abstract available

Keywords: cell signalling; in vitro models; oncology; stem cells; tumour biology.

Publication types

Comparative Study

MeSH terms

Acrylamides / pharmacology
Acrylamides / therapeutic use*
Acrylates / pharmacology
Acrylates / therapeutic use*
Active Transport, Cell Nucleus / drug effects
Analysis of Variance
Animals
Antineoplastic Agents / pharmacology
Antineoplastic Agents / therapeutic use*
Apoptosis / drug effects
Breast Neoplasms / drug therapy
Breast Neoplasms / veterinary*
Carcinoma, Transitional Cell / drug therapy
Carcinoma, Transitional Cell / veterinary*
Cell Line, Tumor
Cell Nucleus / drug effects
Dog Diseases / drug therapy*
Dogs
Female
Hydrazines / pharmacology
Hydrazines / therapeutic use*
Reverse Transcriptase Polymerase Chain Reaction / veterinary
Triazoles / pharmacology
Triazoles / therapeutic use*

Substances

Acrylamides
Acrylates
Antineoplastic Agents
Hydrazines
KPT-185
Triazoles
verdinexor