Engineered Multifunctional Nanomedicine for Simultaneous Stereotactic Chemotherapy and Inhibited Osteolysis in an Orthotopic Model of Bone Metastasis

Adv Mater. 2017 Apr;29(13). doi: 10.1002/adma.201605754. Epub 2017 Jan 30.

Abstract

A novel multifunctional Ag2 S quantum dot (QD)-based nanomedicine of alendronate (Ald)/doxorubicin (DOX)@Ag2 S is developed for highly effective bone tumor therapy in an orthotopic model. The bone-targeting and osteolysis inhibition of Ald and the chemotherapeutic effect of DOX on the bone tumor are in situ visualized by Ag2 S QDs with emission in the second near-infrared window.

Keywords: bone metastasis; molecular imaging; osteolysis inhibition; targeted drug delivery; tumor chemotherapy.

MeSH terms

  • Alendronate / pharmacokinetics
  • Alendronate / pharmacology
  • Animals
  • Antineoplastic Agents / pharmacology*
  • Bone Neoplasms / diagnostic imaging
  • Bone Neoplasms / drug therapy*
  • Bone Neoplasms / physiopathology
  • Bone Neoplasms / secondary*
  • Bone and Bones / diagnostic imaging
  • Bone and Bones / pathology
  • Bone and Bones / physiopathology
  • Cattle
  • Cell Line, Tumor
  • Dose-Response Relationship, Drug
  • Doxorubicin / pharmacokinetics
  • Doxorubicin / pharmacology
  • Drug Delivery Systems*
  • Drug Evaluation, Preclinical
  • Humans
  • Macrophages / drug effects
  • Macrophages / pathology
  • Macrophages / physiology
  • Mice
  • Nanomedicine
  • Neoplasm Transplantation
  • Osteoclasts / drug effects
  • Osteoclasts / pathology
  • Osteoclasts / physiology
  • Osteolysis / diagnostic imaging
  • Osteolysis / drug therapy*
  • Osteolysis / pathology
  • Osteolysis / physiopathology
  • Quantum Dots* / therapeutic use
  • Silver Compounds / pharmacokinetics
  • Silver Compounds / pharmacology

Substances

  • Antineoplastic Agents
  • Silver Compounds
  • Doxorubicin
  • silver sulfide
  • Alendronate