Persistent risk of adult T-cell leukemia/lymphoma after neonatal HTLV-1 infection through exchange transfusion

Eric Oksenhendler; Jocelyn Turpin; Raphael Lhote; Olivier Cassar; Jean-Michel Cayuela; Claire Fieschi; Lionel Galicier; Veronique Meignin; Charles Bangham; Antoine Gessain

doi:10.1007/s12185-016-2174-0

Persistent risk of adult T-cell leukemia/lymphoma after neonatal HTLV-1 infection through exchange transfusion

Int J Hematol. 2017 Jun;105(6):859-862. doi: 10.1007/s12185-016-2174-0. Epub 2017 Jan 30.

Authors

Eric Oksenhendler^{1

2}, Jocelyn Turpin³, Raphael Lhote⁴, Olivier Cassar^{5

6}, Jean-Michel Cayuela⁷, Claire Fieschi^{4

8}, Lionel Galicier⁴, Veronique Meignin⁹, Charles Bangham³, Antoine Gessain^{5

6}

Affiliations

¹ Département d'Immunologie Clinique, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris (APHP), 1 avenue Claude Vellefaux, 75010, Paris, France. [email protected].
² EA3518, Université Paris Diderot Paris 7, Paris, France. [email protected].
³ Section of Virology, Division of Infectious Diseases, Imperial College, London, W2 1PG, UK.
⁴ Département d'Immunologie Clinique, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris (APHP), 1 avenue Claude Vellefaux, 75010, Paris, France.
⁵ Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département de Virologie, Institut Pasteur, 75015, Paris, France.
⁶ CNRS, UMR3569, 75015, Paris, France.
⁷ Laboratoire d'Hématologie, Université Paris-Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, EA3518, Hôpital Saint-Louis, AP-HP, Paris, France.
⁸ Inserm U1126, Centre Hayem, Hôpital Saint-Louis, 1 avenue Claude Vellefaux, Paris, France.
⁹ Department of Pathology, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris (APHP), Paris, France.

PMID: 28138863
DOI: 10.1007/s12185-016-2174-0

Abstract

A 36-year-old Caucasian male presented with adult T-cell leukemia/lymphoma (ATL). HTLV-1 contamination was attributed to a neonatal exchange transfusion. Remission was achieved but 11 years later he presented with symptoms suggesting ATL relapse. Molecular studies of T-cell clonality and virus integration sites revealed a clonal disease, distinct from the first tumor.

Keywords: Adult T-cell leukemia/lymphoma; HTLV-1; Transfusion.

Publication types

Case Reports

MeSH terms

Adult
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Exchange Transfusion, Whole Blood*
Female
Human T-lymphotropic virus 1*
Humans
Leukemia-Lymphoma, Adult T-Cell / drug therapy*
Leukemia-Lymphoma, Adult T-Cell / etiology
Male
Pregnancy
Remission Induction