Quantitative analysis of gadoxetic acid-enhanced magnetic resonance imaging predicts histological grade of hepatocellular carcinoma

Clin Imaging. 2017 May-Jun:43:9-14. doi: 10.1016/j.clinimag.2016.12.009. Epub 2017 Jan 11.

Abstract

Objective: To confirm the histological grade of hepatocellular carcinoma (HCC) by gadoxetic acid-enhanced MRI.

Methods: Ninety-five HCC patients underwent gadoxetic acid-enhanced MRI before surgical intervention. The correlations among the signal absolute enhancement, contrast enhancement ratio (CER) and tumor histological grade were analyzed.

Results: The correlation between CER of tumor-to-liver and the grades of tumor differentiation is the most significant negative. The k-value for the CER of tumor-to-liver and histopathologic analysis is 0.62, which gives evidence of good agreement.

Conclusion: The quantitative analysis of gadoxetic acid-enhanced MRI can predict the histological grades of small HCCs.

Keywords: Gd-EOB-DTPA; Hepatocellular carcinoma; Histological grade; MRI; Quantitative analysis.

Publication types

  • Validation Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Hepatocellular / diagnosis
  • Carcinoma, Hepatocellular / diagnostic imaging
  • Carcinoma, Hepatocellular / pathology*
  • Contrast Media*
  • Female
  • Gadolinium DTPA*
  • Humans
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / pathology*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Neoplasm Grading*
  • Sensitivity and Specificity

Substances

  • Contrast Media
  • gadolinium ethoxybenzyl DTPA
  • Gadolinium DTPA