Paracetamol suppositories: a comparative study

Arch Dis Child. 1989 Oct;64(10):1504-5. doi: 10.1136/adc.64.10.1504.

Abstract

Paracetamol suppositories in two different bases were given to children who had fever after operations. Plasma concentrations and the effect on temperature were compared. There was a significant correlation between peak plasma concentrations and maximum drop in temperature. A lipophilic base produced better results than a hydrophilic base.

Publication types

  • Comparative Study

MeSH terms

  • Acetaminophen / administration & dosage*
  • Acetaminophen / blood
  • Acetaminophen / therapeutic use
  • Adolescent
  • Child
  • Child, Preschool
  • Fever / drug therapy*
  • Humans
  • Infant
  • Postoperative Complications / drug therapy*
  • Suppositories

Substances

  • Suppositories
  • Acetaminophen