Benign prostatic hyperplasia after prostatic arterial embolization in a canine model: A 3T multiparametric MRI and whole-mount step-section pathology correlated longitudinal study

Basen Li; Anhui Xu; Nan Wang; Xiangde Min; Zhaoyan Feng; Ming Deng; Liang Li; Jie Cai; Zhen Kang; Kehua Jiang; Dong Kuang; Liang Wang

doi:10.1002/jmri.25654

Benign prostatic hyperplasia after prostatic arterial embolization in a canine model: A 3T multiparametric MRI and whole-mount step-section pathology correlated longitudinal study

J Magn Reson Imaging. 2017 Oct;46(4):1220-1229. doi: 10.1002/jmri.25654. Epub 2017 Feb 9.

Authors

Basen Li¹, Anhui Xu¹, Nan Wang¹, Xiangde Min¹, Zhaoyan Feng¹, Ming Deng², Liang Li³, Jie Cai⁴, Zhen Kang¹, Kehua Jiang⁵, Dong Kuang⁶, Liang Wang¹

Affiliations

¹ Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.
² Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, P.R. China.
³ Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, P.R. China.
⁴ Department of Interventional Radiology, First People's Hospital of Jingzhou, Yangtze University, Jingzhou, P.R. China.
⁵ Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.
⁶ Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.

PMID: 28182304
DOI: 10.1002/jmri.25654

Abstract

Purpose: To explore the morphological and functional characteristics of prostatic arterial embolization (PAE) in a canine model of benign prostatic hyperplasia (BPH) with 3T multiparametric magnetic resonance imaging (mp-MRI) and whole-mount step-section pathology correlation.

Materials and methods: Eight adult male beagle dogs with hormone-induced BPH underwent 3T mp-MRI before and 1, 3, and 6 months after PAE, with subsequent whole-mount step-section pathologic assessment. Images were acquired using T₁ -weighted images (T₁ WI), T₂ WI, 3D-SPACE, diffusion-weighted imaging (DWI), susceptibility-weighted imaging (SWI), T₂ -mapping, and dynamic contrast-enhanced (DCE) sequences. Variance analysis was performed to assess statistical differences in prostatic volume (PV), apparent diffusion coefficient (ADC), and T₂ values. Pearson correlation analysis was performed to correlate ADC, T₂ , and PV.

Results: The PV decreased from baseline to 1, 3, and 6 months after PAE from (25.88 ± 7.09) cm³ to (6.48 ± 2.08) cm³ , (6.48 ± 3.39) cm³ , (6.20 ± 2.88) cm³ . The ADC values sequentially decreased from baseline to 1, 3, and 6 months after PAE from (1497.06 ± 222.72) × 10^-6 mm² /s to (1056.00 ± 189.46) × 10^-6 mm² /s, (950.48 ± 77.85) × 10^-6 mm² /s, (980.98 ± 107.78) × 10^-6 mm² /s. The T₂ values decreased from baseline to 1, 3, and 6 months after PAE were (83.74 ± 5.29) msec, (68.72 ± 5.66) msec, (53.96 ± 15.04) msec, (49.81 ± 13.34) msec, respectively. ADC and T₂ values were positively correlated with PV (r = 0.823 and 0.744, respectively). Microhemorrhages and hemosiderin were found on SWI after PAE.

Conclusion: 3T mp-MRI may facilitate noninvasive assessment of morphological and functional changes of BPH after PAE.

Level of evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1220-1229.

Keywords: benign prostatic hyperplasia; canine model; magnetic resonance imaging; prostatic arterial embolization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Contrast Media
Disease Models, Animal
Dogs
Embolization, Therapeutic / methods*
Image Enhancement / methods
Longitudinal Studies
Magnetic Resonance Imaging / methods*
Male
Prostate / blood supply*
Prostate / diagnostic imaging*
Prostatic Hyperplasia / diagnostic imaging*
Prostatic Hyperplasia / therapy*

Substances

Contrast Media