Facile and fast preparation of low-cost silica-supported graphitic carbon nitride for solid-phase extraction of fluoroquinolone drugs from environmental waters

J Chromatogr A. 2017 Mar 17:1489:9-17. doi: 10.1016/j.chroma.2017.02.002. Epub 2017 Feb 3.

Abstract

The analytical application of silica-supported graphitic carbon nitride (g-C3N4@silica) for solid-phase extraction (SPE) of fluoroquinolone (FQ) pollutants from water is presented for the first time. g-C3N4@silica was easily and quickly prepared by one-pot thermal condensation of dicyandiamide and characterized by powder X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, Fourier transform infrared spectroscopy and surface area measurements. The novel composite was applied as sorbent for SPE of FQs from water prior high-performance liquid chromatography with fluorescence detection. The extraction efficiency of g-C3N4 was tested in tap and surface waters at actual concentrations (10-100ngL-1). Quantitative adsorption was achieved using 100mg sorbent (20wt% g-C3N4) for pre-concentration of 50-500mL sample, at the native pH (∼7.5-8). Elution was performed with 25mM H3PO4 aqueous solution-acetonitrile (80:20), obtaining recoveries in the range 70-114%, enrichment factors up to 500 and inter-day RSDs≤12%. The batch-to-batch reproducibility was assessed on three independently synthesized g-C3N4@silica preparations (RSD 6-12%). g-C3N4 supported on silica microparticles proved to be of easy preparation, inexpensive, reusable for at least 4 extractions of raw surface waters, and suitable for determination in real matrices.

Keywords: Antibiotics; Determination; Graphitic carbon nitride; Pollutants; Sample enrichment; Sample preparation.

MeSH terms

  • Anti-Bacterial Agents / analysis*
  • Anti-Bacterial Agents / isolation & purification
  • Chromatography, High Pressure Liquid
  • Fluoroquinolones / analysis*
  • Fluoroquinolones / isolation & purification
  • Graphite / chemistry*
  • Nitriles / chemistry*
  • Reproducibility of Results
  • Silicon Dioxide / chemistry
  • Solid Phase Extraction / economics
  • Solid Phase Extraction / methods*
  • Water Pollutants, Chemical / analysis*
  • Water Pollutants, Chemical / isolation & purification

Substances

  • Anti-Bacterial Agents
  • Fluoroquinolones
  • Nitriles
  • Water Pollutants, Chemical
  • cyanogen
  • Silicon Dioxide
  • Graphite