Abstract
We here provide the first report on the construction of nanoparticles formulating highly potent cytotoxic therapeutics using albumin. Maytansinoid DM1 can be efficiently integrated into albumin nanoparticles, resulting in remarkable alleviation of in vivo drug toxicity and expanding the repertoire of albumin technology available for cancer therapy.
MeSH terms
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Albumins / chemistry*
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Animals
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Body Weight / drug effects
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Injections, Intravenous
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Maytansine / administration & dosage
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Maytansine / chemistry
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Maytansine / pharmacology*
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Mice
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Mice, Inbred ICR
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Models, Molecular
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Molecular Conformation
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Nanoparticles / chemistry*
Substances
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Albumins
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Antineoplastic Agents, Phytogenic
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Maytansine