Chenodeoxycholic acid stimulates glucagon-like peptide-1 secretion in patients after Roux-en-Y gastric bypass

Physiol Rep. 2017 Feb;5(3):e13140. doi: 10.14814/phy2.13140. Epub 2017 Feb 14.

Abstract

Postprandial secretion of glucagon-like peptide-1 (GLP-1) is enhanced after Roux-en-Y gastric bypass (RYGB), but the precise molecular mechanisms explaining this remain poorly understood. Plasma concentrations of bile acids (BAs) increase after RYGB, and BAs may act as molecular enhancers of GLP-1 secretion through activation of TGR5-receptors. We aimed to evaluate GLP-1 secretion after oral administration of the primary bile acid chenodeoxycholic acid (CDCA) and the secondary bile acid ursodeoxycholic acid (UDCA) (which are available for oral use) in RYGB-operated participants. Eleven participants (BMI 29.1 ± 1.2, age 37.0 ± 3.2 years, time from RYGB 32.3 ± 1.1 months, weight loss after RYGB 37.0 ± 3.1 kg) were studied in a placebo-controlled, crossover-study. On three different days, participants ingested (1) placebo (water), (2) UDCA 750 mg, (3) CDCA 1250 mg (highest recommended doses). Oral intake of CDCA increased plasma concentrations of GLP-1, C-peptide, glucagon, peptide YY, neurotensin, total bile acids, and fibroblast growth factor 19 significantly compared with placebo (all P < 0.05 for peak and positive incremental area-under-the-curve (piAUC)). All plasma hormone concentrations were unaffected by UDCA Neither UDCA nor CDCA changed glucose, cholecystokinin or glucose-dependent insulinotropic polypeptide (GIP) concentrations. In conclusion, our findings demonstrate that the primary bile acid chenodeoxycholic acid is able to enhance secretion of gut hormones when administered orally in RYGB-operated patients-even in the absence of nutrients.

Keywords: PYY; Bile acids; GLP‐1; Roux‐en‐Y gastric bypass.

Publication types

  • Clinical Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Bile Acids and Salts / blood
  • Blood Glucose
  • C-Peptide / blood
  • Chenodeoxycholic Acid / administration & dosage*
  • Cross-Over Studies
  • Female
  • Fibroblast Growth Factors / blood
  • Gastric Bypass*
  • Glucagon / blood
  • Glucagon-Like Peptide 1 / blood
  • Glucagon-Like Peptide 1 / metabolism*
  • Humans
  • Male
  • Ursodeoxycholic Acid / administration & dosage

Substances

  • Bile Acids and Salts
  • Blood Glucose
  • C-Peptide
  • FGF19 protein, human
  • Chenodeoxycholic Acid
  • Fibroblast Growth Factors
  • Ursodeoxycholic Acid
  • Glucagon-Like Peptide 1
  • Glucagon