Comparison of biodistribution profile of monoclonal antibodies nanoparticles and aptamers in rats with breast cancer

Artif Cells Nanomed Biotechnol. 2017 May;45(3):598-601. doi: 10.3109/21691401.2016.1163717. Epub 2016 Mar 26.

Abstract

The use of monoclonal antibodies and aptamers is growing every single day, as the use of nanoparticle systems. Although most of the products are under investigation, there are a few commercialized products available at the market, for human consume. In this study, we have compared three formulations (aptamer anti-MUC1, monoclonal antibody - Trastuzumab and monoclonal antibodies nanoparticles - PLA/PVA/MMT trastuzumab) to identify their profile as also to understand their behavior into an alive biological system. In this direction the radiolabeling of the products were done and they were all tested in animals (in vivo) in two conditions: healthy rats and breast cancer induced animals. The results showed that the nanoparticle has the better biodistribution profile, followed by the aptamer. We conclude that more studies and a global effort to elucidate the biological behavior of drugs and especially nano-drugs are necessary.

Keywords: Aptamers; nano-radiopharmaceuticals; nanoparticles; radiopharmaceuticals.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacokinetics*
  • Aptamers, Peptide / chemistry
  • Aptamers, Peptide / pharmacokinetics*
  • Female
  • Humans
  • Mammary Glands, Animal / diagnostic imaging*
  • Mammary Glands, Animal / metabolism
  • Mammary Glands, Animal / pathology
  • Mammary Neoplasms, Experimental / diagnostic imaging*
  • Mammary Neoplasms, Experimental / metabolism
  • Mammary Neoplasms, Experimental / pathology
  • Mucin-1 / chemistry
  • Mucin-1 / metabolism
  • Nanoparticles / chemistry
  • Nanoparticles / metabolism
  • Polyesters / chemistry
  • Polyvinyl Alcohol / chemistry
  • Radionuclide Imaging / methods*
  • Radiopharmaceuticals / chemistry
  • Radiopharmaceuticals / pharmacokinetics
  • Rats
  • Rats, Wistar
  • Staining and Labeling / methods
  • Technetium / chemistry
  • Technetium / pharmacokinetics
  • Tissue Distribution
  • Trastuzumab / chemistry
  • Trastuzumab / pharmacokinetics*

Substances

  • Antineoplastic Agents
  • Aptamers, Peptide
  • MUC1 protein, rat
  • Mucin-1
  • Polyesters
  • Radiopharmaceuticals
  • poly(lactide)
  • Technetium
  • Polyvinyl Alcohol
  • Trastuzumab