Interfacing native and non-native peptides: using Affimers to recognise α-helix mimicking foldamers

Irene Arrata; Anna Barnard; Darren C Tomlinson; Andrew J Wilson

doi:10.1039/c6cc09395g

Interfacing native and non-native peptides: using Affimers to recognise α-helix mimicking foldamers

Chem Commun (Camb). 2017 Mar 2;53(19):2834-2837. doi: 10.1039/c6cc09395g.

Authors

Irene Arrata¹, Anna Barnard¹, Darren C Tomlinson², Andrew J Wilson¹

Affiliations

¹ School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK. [email protected] and Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.
² Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK and School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.

PMID: 28217789
DOI: 10.1039/c6cc09395g

Abstract

Selection methods are used to identify Affimers that recognise α-helix mimicking N-alkylated aromatic oligoamides thus demonstrating foldamer and natural α-amino acid codes are compatible.

MeSH terms

Amides / analysis*
Amino Acids / analysis*
Molecular Structure
Peptides / chemistry*
Protein Folding
Protein Structure, Secondary

Substances

Amides
Amino Acids
Peptides