Levels of Intracellular Phosphorylated Tenofovir and Emtricitabine Correlate With Natural Substrate Concentrations in Peripheral Blood Mononuclear Cells of Persons Prescribed Daily Oral Truvada for HIV Pre-exposure Prophylaxis

J Acquir Immune Defic Syndr. 2017 Jul 1;75(3):e86-e88. doi: 10.1097/QAI.0000000000001324.

¹ *Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA †Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD.

No abstract available

Publication types

Adult
CD4-Positive T-Lymphocytes / drug effects*
Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination / pharmacokinetics*
Female
HIV Infections / prevention & control*
HIV Reverse Transcriptase / antagonists & inhibitors
Humans
Lymphocyte Activation / drug effects
Male
Phosphorylation
Pre-Exposure Prophylaxis*
Reverse Transcriptase Inhibitors / pharmacokinetics*
Substrate Specificity
Viral Load