1,2,3-Triazolium-Based Peptoid Oligomers

J Org Chem. 2017 Mar 3;82(5):2386-2398. doi: 10.1021/acs.joc.6b02804. Epub 2017 Feb 22.

Abstract

The cis-directing effect of the 1,2,3-triazolium-type side chain was studied on dimeric peptoid models with various patterns: αα, αβ, βα and ββ. Low influences of the sequence and of the solvent were observed, the cis conformation of the amide carrying the triazolium ranging from 83 to 94% in proportion. The synthesis of peptoid homooligomers with four or eight pendant 1,2,3-triazolium side chains is described. α-, β- and α,β-peptoids carrying propargyl groups were subjected to CuAAC reaction using alkyl azides, and the resulting triazoles were quaternized providing well-defined multitriazolium platforms. The influence of the counteranion (PF6-, BF4- or I-) on the conformation was also studied.

Publication types

  • Research Support, Non-U.S. Gov't