A novel dimorphic pathogen, Emergomyces orientalis (Onygenales), agent of disseminated infection

Mycoses. 2017 May;60(5):310-319. doi: 10.1111/myc.12583. Epub 2017 Feb 27.

Abstract

A novel dimorphic fungus, Emergomyces orientalis sp. nov. a close relative of systemic pathogens in the family Ajellomycetaceae (Blastomyces, Histoplasma). The fungus is reported in a 64-year-old male from Shanxi, China. The patient developed disseminated skin lesions, productive cough with fever and showed nodular opacities in his left lung on chest radiography. The patient had no identified cause of immunodeficiency apart from type-2 diabetes mellitus. Clinical, histopathological and mycological characteristics of the agent are given, and its phylogenetic position is determined with multilocus sequence data.

Keywords: Emergomyces; Emmonsia; AIDS-related mycosis; diabetes; dimorphic fungi; endemic mycosis.

Publication types

  • Case Reports

MeSH terms

  • Blastomyces / genetics
  • China
  • DNA, Ribosomal
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / microbiology
  • Fever / etiology
  • Fever / microbiology
  • Histoplasma / genetics
  • Humans
  • Invasive Fungal Infections / diagnosis*
  • Invasive Fungal Infections / microbiology*
  • Lung / diagnostic imaging
  • Lung / microbiology
  • Lung / pathology
  • Male
  • Middle Aged
  • Multilocus Sequence Typing
  • Onygenales / classification
  • Onygenales / genetics
  • Onygenales / isolation & purification*
  • Onygenales / pathogenicity*
  • Phylogeny*
  • Sequence Analysis, DNA
  • Skin / microbiology
  • Skin / pathology
  • Tomography, X-Ray Computed

Substances

  • DNA, Ribosomal

Associated data

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