Palladium-catalyzed synthesis of monofluoroalkenes from 3,3-difluoropropenes using dimethylmalonate and derivatives as nucleophiles

Org Biomol Chem. 2017 Mar 21;15(11):2376-2384. doi: 10.1039/c7ob00376e. Epub 2017 Feb 28.

Abstract

The synthesis of monofluoroalkenes bearing a malonate or its derivatives at the β position is presented. The reaction can be performed with various 3,3-difluoropropenes. A preliminary result for an enantioselective variant is also reported. Further synthetic transformations of a monofluoroalkene were also accomplished.