G1 cyclins protect pluripotency

Nat Cell Biol. 2017 Mar 1;19(3):149-150. doi: 10.1038/ncb3480.

Abstract

G1 cyclins are considered essential for DNA replication and cell division. A recent report now shows that some cells can cycle in the absence of G1 cyclins. In embryonic stem cells and cancer cells, G1 cyclins are required to activate cyclin-dependent kinases to phosphorylate core pluripotency factors and maintain pluripotency.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Cycle
  • Cyclin G1 / metabolism*
  • Cyclin-Dependent Kinases / metabolism
  • Cytoprotection*
  • Mice
  • Models, Biological
  • Mouse Embryonic Stem Cells / cytology
  • Mouse Embryonic Stem Cells / metabolism
  • Pluripotent Stem Cells / cytology*
  • Pluripotent Stem Cells / metabolism*

Substances

  • Cyclin G1
  • Cyclin-Dependent Kinases