Abstract
A putative growth hormone receptor from rabbit liver and the growth hormone binding protein from rabbit serum have the same amino-terminal amino-acid sequence, indicating that the binding protein corresponds to the extracellular hormone-binding domain of the liver receptor. The complete amino-acid sequences derived from complementary DNA clones encoding the putative human and rabbit growth hormone receptors are not similar to other known proteins, demonstrating a new class of transmembrane receptors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Carrier Proteins / genetics*
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Carrier Proteins / isolation & purification
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Cloning, Molecular*
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DNA / isolation & purification
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DNA / metabolism
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DNA Restriction Enzymes
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Growth Hormone / blood*
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Liver / metabolism
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Molecular Sequence Data
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Rabbits
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Receptors, Somatotropin / genetics*
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Receptors, Somatotropin / isolation & purification
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Transcription, Genetic
Substances
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Carrier Proteins
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Receptors, Somatotropin
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Growth Hormone
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DNA
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DNA Restriction Enzymes
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somatotropin-binding protein