Objective: To investigate the clinical characteristics of ankylosing spondylitis (AS) combined Andersson lesion (AL). Methods: The clinical data of patients who were diagnosed as AS combined AL at Sun Yat-sen Memorial Hospital between January 2012 and December 2015 were reviewed retrospectively.SPSS 20.0 software was used for statistical analysis.Data of normal distribution was expressed by x±s (standard deviation) and that of abnormal distribution by median and range. Results: Fourteen patients were enrolled. Ten were male, median age (IQR, similarly hereinafter) was 46 (29-53) years, disease duration was 120 (54-150) months, 7 has symptom increased in the beginning, 6 has nerve compression symptom, 7 has kyphosis, and 4 has spinous tenderness or percussion pain in physical examination.Eleven of AL occurred in the thoracolumbar junction.Erythrocyte sedimentation rate was 24 (15-44) mm/1 h, C-reactive protein was 10 (5-18) mg/L, and Serum amyloid A was 19 (5-31) mg/L.All the 14 patients were divided into 2 groups, aggravated group (n=7) and none aggravated group (n=7) according to the symptom.It was no statistic difference between them about all the above indicators. Conclusion: Imageological diagnosis should be performed to identify Andersson lesion, while ankylosing spondylitis patients combined mechanical pain based on inflammatory back pain, or mainly with nerve compression symptom, tenderness or percussion pain, or spinous, even when inflammatory markers were normal.
目的：了解强直性脊柱炎合并Andersson损害(Andersson lesion，AL)的特点。 方法：回顾性分析中山大学孙逸仙纪念医院2012年1月至2015年12月住院治疗的强直性脊柱炎合并Andersson损害患者的临床表现及治疗，采用SPSS 20.0软件进行统计学分析，计量资料的统计学描述采用x±s或中位数及四分位间距表示。 结果：共纳入14例患者，其中男10例，中位年龄46(29～53)岁，中位病程120(54～150)个月，7例因腰痛加重就诊，6例合并神经压迫症状，7例有脊柱后凸畸形，4例体格检查发现棘突压痛或叩击痛。11例AL发生在胸腰椎交界节段。红细胞沉降率、C反应蛋白、血清淀粉样蛋白A分别为24(15～44) mm/1 h、10(5～18) mg/L、19(5～31) mg/L。腰痛症状加重组与非加重组比较差异无统计学意义。 结论：强直性脊柱炎患者出现腰痛加重、神经压迫症状、脊柱后凸畸形，炎症标志物可无明显升高，需行影像学检查明确有无Andersson病变。.
Keywords: Andersson lesion; Ankylosing spondylitis.