C-reactive protein (CRP) is a sensitive physiological biomarker of sub-clinical inflammation associated with hyperglycemia, insulin resistance and type 2 diabetic patients. A cross sectional study of 120 subjects attending outpatient department of Mymensingh Medical College, Mymensingh was done with an aim to evaluate serum C-reactive protein in type 2 diabetic patients and compare with age matched non-diabetic persons from July 2014 to June 2015. Of the total cases, 60 were Type 2 diabetic patients and 60 were apparently healthy non-diabetic persons recruited for the study. These diabetic and non-diabetic subjects were classified as male (50%) and female (50%). Fasting blood glucose and CRP were measured by following the standard laboratory methods. The mean CRP level was 16.48±12.69mg/L and <6.00±0.00mg/L in diabetic patients and non-diabetics respectively. The study revealed that fasting blood glucose and C-reactive protein were significantly higher in diabetic patients compared with age matched non-diabetic subjects. There was no significant difference in CRP between diabetic males and diabetic females. It was concluded from the results of this study that, CRP level was elevated in both male and female diabetic patients. These data can support a possible role of inflammatory biomarker in diabetogenesis.