A new neolignan, selamoellenin A (1), was isolated from the whole plants of Selaginella moellendorffii Hieron. The structure was elucidated on the basis of comprehensive spectroscopic methods (1D/2D NMR and HRMS). Compound 1 was evaluated for its protective effect against high glucose-induced human umbilical vein endothelial cells (HUVECs) damage in vitro.
Keywords: HUVECs; Selaginella; Selaginella moellendorffii Hieron; lignans; selamoellenin A.