Abstract
In order to study the electronic effects of 5-substituents of 2'-fluoro-ara-U on antiviral activity, eight nucleosides were synthesized and screened for their activity. Preliminary in vitro studies revealed that 5-thiocyano-, 5-hydroxy- and 5-formyl-ara-U are moderately active against HSV-1, HSV-2 and VZV, but they are also cytotoxic. None of these showed significant activity against CMV.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antiviral Agents / chemical synthesis*
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Arabinofuranosyluracil / analogs & derivatives*
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Arabinofuranosyluracil / chemical synthesis
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Arabinofuranosyluracil / pharmacology
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Drug Evaluation, Preclinical
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Humans
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Simplexvirus / drug effects
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Structure-Activity Relationship
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Uridine / analogs & derivatives*
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Vero Cells
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Vesicular stomatitis Indiana virus / drug effects
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Viral Plaque Assay
Substances
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Antiviral Agents
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Arabinofuranosyluracil
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Uridine